Bob Marley died of malignant melanoma found underneath his toenail diagnosed in 1977. Legend has it that he got the lesion from a football game injury earlier in the year. Actually, he got it from pre-existing cancer.
Doctors told him to amputate his toe, but he refused on the basis of religious beliefs. Even though he was sick, he continued touring and working. He even planned another tour for 1980 when he was taken. His 1980 album, Uprising, was made as a way for Marley to come to terms with his mortality. He completed his tour in Europe and two concerts in the U.S.
The cancer spread throughout his body and he became extremely ill. He cancelled his tour and went to a Bavarian clinic. He was treated for 8 months by watching his food, water, and substance intake. He headed back to Jamaica when he was near death's door. He only made it to Miami, though. He died in Cedars of Lebanon Hospital.
His final words to his son, Ziggy, were "Money can't buy life." He was given a state funeral in Jamaica combining Ethiopian Orthodoxy and Rastafarian traditions. He was then buried in a chapel near where he was born.