Titan, the moon of Saturn, is one of a few candidates for a human colony in the future. The surface gravity on Titan is 0.14g, which is slightly less than the gravity on the Moon. Such low gravity would obviously have long term effects on human health, and would probably be an ongoing issue of high significance.
Long exposure to low gravity can cause a loss in bone density, muscle density, and a weakened immune system. Similar things have happened to astronauts who have remained in space for long periods of time. Still, the best countermeasure to this is frequent exercise.
It’s been hypothesized that children born on Titan would adapt to the low gravity atmosphere and therefore would not be able to live a normal life on Earth. The atmospheric pressure on Titan is also one and a half times that of Earth. That means crafts would have a much easier time landing compared to bodies like Mars or the Moon. Titan’s atmosphere, however, contains hydrogen cyanide, which isn’t too good for humans to breathe. In this respect it would require severe terraforming.
But because of the gravity and atmospheric pressure, the wingspan needed for a craft to fly is much smaller. In fact, it’s so much smaller that a human could, in theory, strap on wings and fly through the air with ease.